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The importance of heavy metals in bacterial conjugation efficiency to enhance the spread of antibiotic resistance genes in environment

With an anticipated yearly death toll of roughly 700,000, antibiotic resistance is growing at an unexpected speed. Antibiotic-resistant bacteria (ARB) can be found in a variety of habitats and can spread their resistance genes to other organisms through processes like conjugation and horizontal gene transfer. Under particular environmental conditions, several heavy metals, such as iron (Fe), zinc (Zn), copper (Cu), etc., which can be found in any natural/industrial area, can increase or reduce the conjugation efficiency between bacteria. Analyzing the role of some heavy metal particles with specific concentrations on bacterial conjugation under a designated condition can improve the present knowledge regarding their effects on the proliferation of antibiotic resistance. In addition, prospective results can be favorable to improve the nationwide guidelines to limit the acceptable levels of certain types of heavy metals in the effluents before releasing into the environment.

• 23/09/2015 – 20/06/2018: M.Sc. in Microbial Biotechnology, Islamic Azad University Tehran, Iran
• 23/09/2010 – 22/07/2014: B.Sc. in Biotechnology, Islamic Azad University, Lahijan, Iran

• MEXT Scholarship grant (IESLP program, September 2022-September 2024)

1. New association between diabetes mellitus and pancreatic cancer
   Monireh Rezaei, Zinat Shams, Bahareh Sadat Rasouli, Katayoun Dadeh Amirfard, Mohadeseh Soleymani Sadrabadi, Ali Gheysarzadeh, Karimeh Haghani and Salar Bakhtiyari
   Current Diabetes Reviews, 2023, 19(1), 80-91.
   DOI: 10.2174/1573399818666220118095952
2. Efficacy of green tea extract on PC3 prostate cancer cells through upregulation of miR-195 expression and suppression of epithelial to mesenchymal transition
   Fatemeh Safari, Katayoun Dadeh Amirfard
   Journal of Traditional Chinese Medicine, 2022, 42(5), 681-686
   DOI: 10.19852/j.cnki.jtcm.2022.05.002
3. Acinetobacter spp. and Stenotrophomonas acidaminiphila strain pars1396 isolated from landfill soil and industrial wastewater as potential candidates for phenol biodegradation
   Katayoun Dadeh Amirfard, Mohammad Javad Mehdipour Moghaddam, Farzaneh Hosseini
   Biology and Environment: Proceedings of the Royal Irish Academy, 2021, 121B(3), 163-174.
   DOI: 10.1353/bae.2021.0013

1. The importance of nutrient levels and combined chlorination on ARG transfer through conjugation between Photobacterium damselae sp. damselae 04Ya311 and a recipient isolated from wastewater influent  (poster presentation)
   Katayoun Dadeh Amirfard, Momoko Moriyama, Daisuke Sano
   5th Academic Forum on Environmental Studies
   October 27, 2023, GSES Main Building, Tohoku University. Japan.
2. Transcriptome mining revealed new association between diabetes and pancreatic cancer (poster presentation)
   Rezaei, M; Shams, Z; Rasouli, S. B; Amirfard, D. K; Sadrabadi, S.M; Bakhtiyari, Salar.
   The 7th National & 1st International Seminar/Webinar in Medical Genetics: Diagnostics & Research
   April 8-9, 2021, Sanandaj, Iran.